Very good contest and great question. I started out putting both weights in the 440 & the 460 back, or neutral. Then quickly realized that a little forward was better, and a little more forward was even better, then all the way forward in the 460 turned the driver into a ROCKET LAUNCHER. In the 440, you'll notice that the back weight is a little forward, that setting was the best for me w/the 440. Makes sense with a lower spinning head to begin with. Went into my testing thinking the 440 was for me (It's still a very good club, the number show that), came out knowing the 460 (with a little more forgiveness for me) in this setting was taylor made for me, get it.. Taylormade for me!
I'm 6'8" and have a large swing arc so I tend to hit a pretty high ball. The back weight is adjusted slightly to the low side to keep the ball flight a little more appealing and piercing. I hit a natural draw but wanted a bit more on it so the center weight is just slightly off-center favoring the draw side.
Front weight set to fade to offset an occasional hook or pull. Back weight set to high to optimize launch and forgiveness. Love this driver, but would take an M3 if I was lucky enough to win.
I set both my weights clear to the back for maximum forgiveness. I use a 4 inch tee off my left heel and use a fairly wide stance. Works for me as it is usually straight down the fairway.